Identification of Small Molecule from Jorunna Funebris with Anti-lung Cancer Potential: Molecular Modeling Study

Abstract

Methionine Aminopeptidase 2 (MetAP2) is an enzyme that plays a vital role in regulating posttranslational processing and protein synthesis. MetAP2 is overexpressed in non-small cell lung cancer (NSCLC). Potential cytotoxicity of Jorunnamycin A-C from Jorunna funebris, has been reported, but the mechanism of action is unclear. The study aims to investigate the molecular interaction between Jorunnamycin A-C and MetAP2 by molecular modeling. The results showed that Jorunnamycin A is the most promising inhibitor of MetAP2. This finding provides a better understanding of the molecular basis for the cytotoxicity of Jorunna funebris.